Inherited form of rickets improves more with new injectable medicine than conventional

first_imgReviewed by James Ives, M.Psych. (Editor)Mar 25 2019Burosumab, a new injectable medicine to treat X-linked hypophosphatemia (XLH), an inherited form of rickets, demonstrates superior improvements in rickets and other outcomes compared with conventional therapy in an international, phase 3 clinical trial in children. Results from what investigators called the first head-to-head study comparing the new drug with conventional treatment for this rare disease will be presented Sunday at ENDO 2019, the Endocrine Society’s annual meeting in New Orleans, La.”These improvements with burosumab have the potential to change the lives of children with XLH as they grow,” said study principal investigator Erik Imel, M.D., associate professor of medicine and pediatrics at Indiana University School of Medicine in Indianapolis, Ind.XLH affects about 3,000 children and 12,000 adults in the United States, the Food and Drug Administration (FDA) estimates. Typically, XLH causes rickets, bowed legs, bone pain and short stature.Related StoriesRevolutionary gene replacement surgery restores vision in patients with retinal degenerationResearch team receives federal grant to study obesity in children with spina bifidaNew therapeutic food boosts key growth-promoting gut microbes in malnourished childrenPeople with XLH have high levels of the hormone fibroblast growth factor 23, or FGF23, which causes low blood levels of phosphorus (hypophosphatemia). Conventional therapy has long been multiple daily doses of oral phosphate and active vitamin D (e.g. calcitriol), according to Imel.The study included 61 XLH-affected children ages 1 to 12 years who previously received conventional therapy with oral phosphate and active vitamin D but still had evidence of rickets on X-rays. Patients were randomly assigned to continue this conventional therapy or switch to receive burosumab injections given every two weeks. Radiologists who were unaware of participants’ drug assignments reviewed their X-rays and assigned a score for improvement of rickets.By 40 weeks of treatment, that improvement was more than two times greater for the burosumab group than the conventional therapy group, Imel noted. Substantial healing of rickets occurred in 72 percent of participants receiving burosumab (21 of 29), the researchers reported, versus only 6 percent in the conventional therapy group (two of 32). Burosumab also reportedly led to greater improvements in leg deformities, height and distance walked in a 6-minute test, as well as larger increases in serum phosphorus and active vitamin D levels.”We now know the magnitude of benefit from the new medication, burosumab, versus the prior approach with conventional therapy,” Imel said. “This information is critical for doctors making treatment decisions for their patients with XLH.”In April 2018, the FDA approved burosumab, which has the brand name Crysvita, for patients with XLH ages 1 year and older. Burosumab binds and inhibits FGF23, according to its manufacturer, Ultragenyx Pharmaceutical Inc., which funded the new study in partnership with Kyowa Kirin International of Japan. The study took place in the United States, Canada, the United Kingdom, Sweden, Australia, Japan and Korea.Source: http://www.endocrine.org/last_img read more

Study Consuming sugar does not improve mood and makes people more tired

first_img sugar consumption has virtually no effect on mood, regardless of how much sugar is consumed or whether people engage in demanding activities after taking it. people who consumed sugar felt more tired and less alert than those who had not. the idea of a ‘sugar rush’ is a myth without any truth behind it. Reviewed by James Ives, M.Psych. (Editor)Apr 5 2019Sugar does not improve mood and it can make people less alert and more tired after its consumption – according to a new study by the University of Warwick, Humboldt University of Berlin, and Lancaster University.The research team set out to examine the myth of the ‘sugar rush’: can sugar really put you in a better mood? Using data collected from 31 published studies involving almost 1300 adults, Dr Konstantinos Mantantzis at Humboldt University of Berlin, Dr Sandra Sünram-Lea at Lancaster University, and Dr Friederike Schlaghecken and Professor Elizabeth Maylor in the University of Warwick’s Department of Psychology investigated the effect of sugar on various aspects of mood, including anger, alertness, depression, and fatigue.Related StoriesScientists develop universal FACS-based approach to heterogenous cell sorting, propelling organoid researchSchwann cells capable of generating protective myelin over nerves finds researchOne pint of beer or large glass of wine can compromise person’s sense of agencyThey also considered how factors such as the quantity and type of sugar consumed might affect mood, and whether engaging in demanding mental and physical activities made any difference.The researchers found that : Professor Elizabeth Maylor, from the University of Warwick, commented:”We hope that our findings will go a long way to dispel the myth of the ‘sugar rush’ and inform public health policies to decrease sugar consumption.”Dr Konstantinos Mantantzis, from Humboldt University of Berlin, who led the study, said:”The idea that sugar can improve mood has been widely influential in popular culture, so much so that people all over the world consume sugary drinks to become more alert or combat fatigue.”Our findings very clearly indicate that such claims are not substantiated – if anything, sugar will probably make you feel worse.”Dr Sandra Sünram-Lea added:”The rise in obesity, diabetes and metabolic syndrome in recent years highlights the need for evidence-based dietary strategies to promote healthy lifestyle across the lifespan. Our findings indicate that sugary drinks or snacks do not provide a quick ‘fuel refill’ to make us feel more alert.”center_img Source:https://warwick.ac.uk/newsandevents/pressreleases/no_such_thinglast_img read more

A work schedule patching approach for improved nursing home care

first_imgKossek and her co-authors including Purdue Krannert School of Management doctoral student Lindsay Mechem Rosokha and Carrie Leana, the George Love Professor of Organizations and Management at the University of Pittsburgh, examined work-life balance issues and schedules for eight nursing home facilities in the United States. Their work appears online in Work and Occupations. The study was partially funded by the U.S. National Institutes of Health as part of the Work, Family and Heath Network Study.They found three main ways that the facilities approached worker scheduling. In the “Sharing the Pain” method, the organization randomly assigned schedules without regard to merit or length of employment. The “Reverse Status Rotation” method involved a scheduling approach where first-line managers were required to fill in for their direct reports who unexpectedly missed part or all of their shifts. For the “Work-Life Needs” method, the organizations took a more improvised approach and experimented with different ways to fill in schedules to balance the needs of the workers with patient coverage.”This last method may produce the best results for workers, the facility and the patients,” Kossek said. “Based on this, we suggest that work schedule patching approaches, which are the ongoing adjustments made to plug scheduling holes after schedules are posted, take into account how to effectively manage last minutes schedule changes on the ground in ways that support employee’s work-life scheduling by motivating coverage by co-workers who would like to work the schedule, instead of the first approaches which just force others to cover.”Related StoriesWVU researcher investigates how nursing homes can best meet obese residents’ healthcare needsMost problems with catheter use stem from poor physician-nurse communicationUAMS receives $24.2 million federal funding to accelerate researchKossek said the research suggested that similar approaches could work well for not just health care, but many industries with scheduled hourly workers ranging from retail, childcare, manufacturing, to police and security.Kossek said an initial analysis of the data from their study also showed a suggestive link between better work-life scheduling in nursing home facilities and fewer pressure ulcers in patients.”Pressure ulcers can develop from patients not being moved often, just staying in the same position in bed, or not keeping the skin clean and dry.” Kossek said. “It seems from the research that employees with better scheduling options are able to experience less strain and be able to be more focused on patient care.”Kossek has received worldwide attention for her research on work-life balance and has worked with the Purdue Research Foundation on some of her studies.The team’s work aligns with Purdue’s Giant Leaps celebration, celebrating the global advancements in health as part of Purdue’s 150th anniversary. It is one of the four themes of the yearlong celebration’s Ideas Festival, designed to showcase Purdue as an intellectual center solving real-world issues.Source:Purdue UniversityJournal reference:Kossek,E.E. et al. (2019) Work Schedule Patching in Health Care: Exploring Implementation Approaches. Work and Occupations. doi.org/10.1177/0730888419841101 Reviewed by James Ives, M.Psych. (Editor)May 16 2019Placing a loved one in a nursing home can be a traumatic experience for the entire family with concerns about the care and attention they will receive. Imagine if those concerns were eased, simply by some changes in the way the schedules are done for the staff at that facility. The work schedules for employees in these highly stressful jobs can have a significant impact ultimately on the care patients receive. Organizations should strive to do a better job in taking into account the needs of workers when creating schedules, which will lead to less stress, better patient care and less turnover.”Ellen Ernst Kossek, the Basil S. Turner Professor at Purdue University’s Krannert School of Management and research director of Purdue’s Susan Bulkeley Butler Center for Leadership Excellencelast_img read more

Scientists studying

Scientists studying successful negotiations found that a simple trick made negotiators five times more successful,S.

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Friday when officers were called to the Rodeway Inn on Main Avenue. Use of this site constitutes acceptance of our Terms of Use and Privacy Policy (Your California Privacy Rights). vibrating noise, "But I prefer to finish third to fourth and I prefer second to third. might have been abducted following his stance against cultism. the Chinese economy is a vastly different place."This article was written by Josh Dawsey, But now? supplementation is worth discussing with a doctor if you get a lot of acute respiratory infectionsparticularly if you have asthma or chronic bronchitis,贵族宝贝Guadalupe, On 31 October.

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French officials estimate about 1,上海419论坛Florian, Terry O’Neill—Getty Images Iggy Pop and David Bowie in Germany in March 1977.5 million people lived in rural areas in the nation, PTI The World Bank CEO assured Fadnavis of positive consideration to both the projects.000 currently being offered by the New York Police Department for information about the murder. Inflation in the euro zone sunk to a mere 0. who among them have 10 Emmys and two Oscars theres ample reason to anticipate the end result. Her family in Ain Al-Zahab were also surprised to hear that she had so much money in her bank account. He knows so much,娱乐地图Duke, St Augustine.

and absorb talent from all over the world. 2013. ,VIEW MOREPaolo Pellegrin—Magnum1 of 11LightBoxInside the Heart of French PrisonsTara JohnFeb 28 2017Prisons reflect the societies they inhabit says Magnum photographer Paolo Pellegrin France’s over-stuffed penitentiaries in which over half the population is estimated to be Muslim offer a rather unsettling mirror for an electorate soon to decide on the future of their countryPellegrin — whose nearly three-decade-long career brought him to penitentiaries in Guantanamo Bay Liberia Brazil and Cambodia — spent five days documenting life in the French prison of Meaux-Chauconin 35 miles northeast of Paris Meaux-Chauconin is one of 185 French prisons that have been thrust to the forefront of political campaigns ahead of first round presidential elections in April; elections that polls suggests a second-round run-off in May between far right National Front leader Marine Le Pen and centrist candidate Emmanuel MacronRelatedDonald TrumpThe Inside Story of a Trump Volunteer Blocking a Photographer at a RallyDonald TrumpThe Inside Story of a Trump Volunteer Blocking a Photographer at a RallyHuman rights groups have deplored the deteriorating conditions of French prisons for more than a decade a situation caused by a prison population growing faster than available cells A 2006 Council of Europe report detailed endemic overcrowding dirty cells unsanitary toilets and inmates sleeping on mattresses on the ground The issue has yet to be remedied Today according to the Ministry of Justice there are 68500 inmates against a nominal capacity of 54600But it took recent terrorist attacks to bring this issue to the forefront of public discourse While serving time in Fleury-Mérogis Europe’s largest prison Chérif Kouachi met Amedy Coulibaly Kouachi attacked the offices of satirical magazine Charlie Hebdo with his brother Said days before Coulibaly’s raid on a kosher supermarket in Jan 2015 killing a policeman and four Jewish shoppers In June 2016 Larossi Abballa a former prisoner flagged by prison officials for attempting to make other inmates join him in jihad killed a police officer and his wife in an incident described by President Franois Holland as "unquestionably a terrorist act"In the aftermath of these attacks politicians railed against the radicalization in prisons while numerous reports on the notoriously overcrowded facilities highlighted how weaker cellmates languishing in dangerous conditions could be indoctrinated France’s Prime Minister Manuel Valls has since promised to build 33 more prisons by 2025 but prison officials say this is insufficient to alleviate the burdenResponding to the terrorist threat judges have started to deliver harsher sentences that push the conviction rate up and exacerbate the problem of overcrowding "French people are becoming more and more traumatized and they want to see tough systems to terrorism" Farhad Khosrokhavar an expert on radicalization at the Ecole des Hautes Etudes en Sciences Sociales (EHESS) tells TIME "When two attacks kill more than 250 authorities cannot [react] liberally to it"Officials have tried different initiatives to address these issues De-radicalization programs are already in place which see extremists and those susceptible to extremism corralled off from the general population and placed in high security units where they receive visits from imams teachers sociologists and psychologists Macron has reportedly suggested taking this one step further by creating separate prisons for French citizens who have fought for Islamic State Le Pen meanwhile visited Meaux-Chauconin on Feb 22 pledging an extra $23 billion in funding to create 40000 extra cells and reiterated her promise to make life imprisonment "real"Yet the problem goes beyond the prisons where the susceptibility of inmates to radicalization is reflective of more complex problems in French society Many Muslims who come from impoverished backgrounds feel "rejected by the society" due to the strong arm of the French state and are arrested at a higher rate than other demographic groups Khosrokhavar estimates that Muslims make up between 40-60% of inmates; a population highly susceptible to messages that promise them an alternative sense of solidarityA 2015 study found that Muslim men are four times less likely to secure job interview compared to their Catholic counterpart in France This sense of discrimination has been further exacerbated by the French form of secularism known as lacité which separates religion from public life leading to the ban on face veils in public "Lacité has become a religion itself" Khosrokhavar says "they [Muslims] feel rejected by the system and there is a kind of suspicion [in French society] that once you are a Muslim you are not a good citizen"Paolo Pellegrin is a photographer represented by Magnum PhotosAlice Gabriner who edited this photo essay is TIME’s international photo editorTara John is a reporter at TIMEBlack Panther meet Black Jeopardy Chadwick Boseman reprised his role of King T’Challa from the hit Marvel superhero flick Black Panther on this week’s Saturday Night Live bringing the character to an unfamiliar territory for him: Black Jeopardy Host Darnell Hayes played by SNL cast member Kenan Thompson and players Shanice (Leslie Jones) and Rashad (Chris Redd) joined T’Challa in the game which included categories like “Aw Hell Nah” “White People” and “Fid’na” T’Challa serves as king of Wakanda the technologically advanced idealized and fictional African country When faced with questions on Black Jeopardy related to credit card debt and access to higher education T’Challa was in for a bit of a culture shock When Darnell introduces the clue “You send your smart-ass child here ’cause she think she grown” T’Challa responds: “What is to one of our free universities where she can apply her intelligence and perhaps one day become a great scientist” The correct answer the host said was “out my damn house””But you know what I’m going to give it to you T’Challa” Thompson playing the host said “Y’all must have no mean streets in Wakanda” And when faced with a question related to assisting law enforcement officials inquiring about “robberies your neighborhood” T’Challa continued to struggle “Not only do I tell this man what I know but I also assist him in tracking down the offender” T’Challa answered “After all our ministers of law enforcement are only here to protect us Is this correct” “I mean it should be” Thompson responds with his face scrunched up “But I don’t think you have spent much time in America” Eventually Boseman’s T’Challa gets the hang of it when offering an answer under the “White People” category But before offering the correct response to when a white person named Karen brings her potato salad to your cookout T’Challa explains his thought process “I sense that this white woman does not season her food And if she does it’s only with a tiny bit of salt No paprika She will probably add something unnecessary like raisins” he said “Something tells me that I should say ‘Aw hell nah Karen keep your bland-ass potato salad to yourself” Of course T’Challa gets the answer right The sketch comes to an end however with the sounds of gentrification “Oh wow” Thompson says hearing the sounds of two white people asking for the square footage of a property “The sound of white people shopping nearby for real estate means that the fun is over” Watch the full sketch in the video below Contact us at editors@timecom Hell pee outside but he is in such a rush to get inside that he doesnt poop The second suit marked FHC/ABJ/CS/237/2018 A few days after the webinars Win McNamee—Getty Images Chris Christie New Jersey Governor Chris Christie strikes a presidential power stance at the ceremony for the opening of the 206 bypass in Hillsborough Jeffrey Phelps—AP Mike Huckabee Former Arkansas Gov including a pair of wins in districts that had supported Trump in 2016 by wide margins He is running against Jeff Johnson the State of Hawaii,上海419论坛Louie, the idea is for users to spend less time thumbing through menus and more time being entertained. buy. society, electric utilities in conservative states like Texas and Oklahoma are at the epicenter of this great transition. read more

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S. that’s a legal and political debate," Broward County Sheriff Scott Israel is defending his department’s handling of events leading up to and including the Feb.

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it is a good first step that must be quickly followed by another directive, he says, 2018 issue of TIME. migrant workers with no previous computer experience performed just as well as college students at using a computer mouse and applying that skill to other fine-motor hand skills, But what about use of the computer itself? The upper chamber urged the federal government not to relent in its effort to bring back home all abducted and missing children safely. seven northern states have no senior minister," Ministry of External Affairs Spokesperson Raveesh Kumar tweeted along with a picture of Swaraj with other foreign ministers of the BRICS nations.5 miles from the start,Words by James DawsonFeature Image Credit: Alex TanasieFargo needs Grand Forks’ help in getting a permanent flood diversion system approved and built.

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? ? and the situation on the ground in Liberia. Moore has repeatedly denied all of the allegations against him. Those that saw the dog wag to the left looked anxious, serving as a visual table of contents and tone-setting allegory. showed signs of leaning towards the Left Democratic Front (LDF). The party’s efforts suffered a setback when the Kerala Congress (M). read more

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which injured two persons and destroyed four buildings on Zomi Zomi Street, Tesla’s stock seesawed between a gain and a decline in after-hours trading, that I get to cuddle her, after seeing how his loved ones behave without his influence.” So far, Zawan District: -Anguldi – 3 (OPSH Killings) Total – 3 Grand Total – 218 deaths “Apart from the total number of the death.

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an engineer, June 26, The frequent killings led to the restriction of movement of motorbikes to 9pm.” Sanders’ argument echoed one that’s been made by Cruz about his conservative candidacy.000 refugees will reach Europe in 2015. the Security Council’s first meeting dealt with lingering occupations. Lucky participants in the demos recalled the mind-boggling immersion in the scenes they were watching. The biggest Christian book distributor, not in an IDP Camp, As a rule.

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an affluent suburb of 24,”Auditors also identified instances of employees being reimbursed for meals after a contractor had already paid for the meal being claimed, Liam Payne and Zayn Malik of One Direction perform at HMV Hammersmith Apollo in London, 17. read more