Modifying DNA May Wipe Away Old Memories

first_imgA clean slate—that’s what people suffering from posttraumatic stress disorder (PTSD) crave most with their memories. Psychotherapy is more effective at muting more recent traumatic events than those from long ago, but a new study in mice shows that modifying the molecules that attach to our DNA may offer a route to quashing painful memories in both cases.  One of the most effective treatments for PTSD is exposure psychotherapy. A behavioral psychologist asks a patient to recall and confront a traumatic event; each time the traumatic memory is revisited, it becomes susceptible to editing through a phenomenon known as memory reconsolidation. As the person relives, for example, a car crash, the details of the event—such as the color and make of the vehicle—gradually uncouple from the anxiety, reducing the likelihood of a panic attack the next time the patient sees, say, a red Mazda. Repeated therapy sessions can also lead to memory extinction, in which the fears tied to an event fade away as old memories are replaced with new ones.Yet this therapy works only for recent memories. If too much time passes before intervention, the haunting visions become stalwart, refusing to budge from the crevices of the mind. This persistence raises the question of how the brain tells the age of a memory in the first place.Sign up for our daily newsletterGet more great content like this delivered right to you!Country *AfghanistanAland IslandsAlbaniaAlgeriaAndorraAngolaAnguillaAntarcticaAntigua and BarbudaArgentinaArmeniaArubaAustraliaAustriaAzerbaijanBahamasBahrainBangladeshBarbadosBelarusBelgiumBelizeBeninBermudaBhutanBolivia, Plurinational State ofBonaire, Sint Eustatius and SabaBosnia and HerzegovinaBotswanaBouvet IslandBrazilBritish Indian Ocean TerritoryBrunei DarussalamBulgariaBurkina FasoBurundiCambodiaCameroonCanadaCape VerdeCayman IslandsCentral African RepublicChadChileChinaChristmas IslandCocos (Keeling) IslandsColombiaComorosCongoCongo, The Democratic Republic of theCook IslandsCosta RicaCote D’IvoireCroatiaCubaCuraçaoCyprusCzech RepublicDenmarkDjiboutiDominicaDominican RepublicEcuadorEgyptEl SalvadorEquatorial GuineaEritreaEstoniaEthiopiaFalkland Islands (Malvinas)Faroe IslandsFijiFinlandFranceFrench GuianaFrench PolynesiaFrench Southern TerritoriesGabonGambiaGeorgiaGermanyGhanaGibraltarGreeceGreenlandGrenadaGuadeloupeGuatemalaGuernseyGuineaGuinea-BissauGuyanaHaitiHeard Island and Mcdonald IslandsHoly See (Vatican City State)HondurasHong KongHungaryIcelandIndiaIndonesiaIran, Islamic Republic ofIraqIrelandIsle of ManIsraelItalyJamaicaJapanJerseyJordanKazakhstanKenyaKiribatiKorea, Democratic People’s Republic ofKorea, Republic ofKuwaitKyrgyzstanLao People’s Democratic RepublicLatviaLebanonLesothoLiberiaLibyan Arab JamahiriyaLiechtensteinLithuaniaLuxembourgMacaoMacedonia, The Former Yugoslav Republic ofMadagascarMalawiMalaysiaMaldivesMaliMaltaMartiniqueMauritaniaMauritiusMayotteMexicoMoldova, Republic ofMonacoMongoliaMontenegroMontserratMoroccoMozambiqueMyanmarNamibiaNauruNepalNetherlandsNew CaledoniaNew ZealandNicaraguaNigerNigeriaNiueNorfolk IslandNorwayOmanPakistanPalestinianPanamaPapua New GuineaParaguayPeruPhilippinesPitcairnPolandPortugalQatarReunionRomaniaRussian FederationRWANDASaint Barthélemy Saint Helena, Ascension and Tristan da CunhaSaint Kitts and NevisSaint LuciaSaint Martin (French part)Saint Pierre and MiquelonSaint Vincent and the GrenadinesSamoaSan MarinoSao Tome and PrincipeSaudi ArabiaSenegalSerbiaSeychellesSierra LeoneSingaporeSint Maarten (Dutch part)SlovakiaSloveniaSolomon IslandsSomaliaSouth AfricaSouth Georgia and the South Sandwich IslandsSouth SudanSpainSri LankaSudanSurinameSvalbard and Jan MayenSwazilandSwedenSwitzerlandSyrian Arab RepublicTaiwanTajikistanTanzania, United Republic ofThailandTimor-LesteTogoTokelauTongaTrinidad and TobagoTunisiaTurkeyTurkmenistanTurks and Caicos IslandsTuvaluUgandaUkraineUnited Arab EmiratesUnited KingdomUnited StatesUruguayUzbekistanVanuatuVenezuela, Bolivarian Republic ofVietnamVirgin Islands, BritishWallis and FutunaWestern SaharaYemenZambiaZimbabweI also wish to receive emails from AAAS/Science and Science advertisers, including information on products, services and special offers which may include but are not limited to news, careers information & upcoming events.Required fields are included by an asterisk(*)Researchers at the Massachusetts Institute of Technology, led by neurobiologist Li-Huei Tsai, have now uncovered a chemical modification of DNA that regulates gene activity and dictates whether a memory is too old for reconsolidation in mice. A drug that tweaks these “memory wrinkles” gives old memories a face-lift, allowing them to be edited by reconsolidation and resulting in fear extinction during behavior therapy.In the new study, published online this week in Cell, the researchers instilled traumatic memories in mice by placing them in an unfamiliar cage and immediately giving them an electrical shock to their feet. The rodents quickly became terrified of the cage, and when returned to the setting, they instantly froze in anticipation of a shock.Once the researchers had instilled the fear memory, they repeatedly returned the mice to the cage without the shock, either 24 hours or 30 days later. Rodents given this behavior therapy 24 hours after the jolts eventually stopped freezing, suggesting that reconsolidation and memory extinction were erasing the anxiety connected with the cage. But if the researchers returned the animals to the cage after 30 days, the mice remained afraid, indicating that older or “remote” memories were less forgettable.Prior work on rodents has shown that the reconsolidation update stage—the point when a recalled memory is most vulnerable to change—parallels an increase in so-called histone acetylation to DNA. DNA spools around proteins known as histones like yarn, and gene activity shuts down in the tightly wrapped regions. Acetylation, or the addition of an acetate molecule to the histone, loosens the DNA, turning these genes back on. (Such chemical modifications to DNA are known as epigenetic modifications, and they have been linked to everything from obesity to Alzheimer’s disease.) To keep the genetic material tightly bundled, a family of enzymes—called HDACs—surfs the DNA, preventing histone acetylation.The new study reveals that one of these enzymes—HDAC2—patrols genes in the mouse hippocampus, a brain region responsible for learning and memory. However, the researchers found that HDAC2 performs this job only when older memories are being reconsolidated, not when recent memories are facing a similar update. The key difference was a biochemical change to HDAC2 called nitrosylation. HDAC2 was nitrosylated within 30 minutes of recalling recent memories, but not with remote recollections. Thus, nitrosylation appears to serve as an on-and-off switch that denotes the age of a memory.Many studies have shown that epigenetic changes are fundamental to learning, but Tsai’s work goes a step beyond this, says Jelena Radulovic, a psychiatrist and molecular pharmacologist at Northwestern University’s Feinberg School of Medicine in Chicago, Illinois, who was not involved with the current research. “Specific nitrosylation of HDAC2 obviously affects several genes important for reconsolidation updates—apparently as memories age, this mechanism fails.”When Tsai’s team switched off HDAC2 with a drug, reconsolidation of remote fear memories occurred after behavior therapy. Thus, anxiety resulting from older traumas was wiped away akin to more recent memories. These findings paralleled an enhancement of neuroplasticity—genetic and structural changes in neurons—within the hippocampus, which are indicative of memory reshaping. Glucose metabolism in the hippocampus, a broad estimate of learning capacity, was also boosted in this series of experiments.This is the first study to attenuate remote—older—fear memories in an animal model, according to the authors.If the findings apply to humans, the potential uses of HDAC inhibitors would extend far beyond the realm of PTSD, says Kerry Ressler, a psychiatrist at Emory University in Atlanta, who was not involved with the study. “The basic idea of exposure therapy holds across a number of anxiety and fear-related disorders, including PTSD, panic disorder, and phobias like fear of heights, where fear memories are often more remote,” Ressler says. Combining psychotherapy with a drug that augments memory retrieval could access these deeply buried fear memories, while also reducing the number of sessions a patient needs to eliminate their anxiety, he says.last_img read more

Thousands of migratory birds die mysteriously in Rajasthan’s Sambhar Lake

first_imgCivic workers prepare to bury birds which were found dead at the Sambhar Salt Lake in Rajasthan, Monday, Nov. 11, 2019. Thousands of migratory birds of about ten species were found dead around Sambhar Lake, the country’s largest inland saltwater lake near Jaipur, sending shock waves among locals and authorities.Officials said they suspect water contamination as one of the reasons for the deaths but were awaiting viscera test reports. Though the official toll was 1,500, locals claimed the number of dead birds could be as high as 5,000.“We have never seen anything like that. Over 5,000 birds died mysteriously all over the place,” 25-year-old Abhinav Vaishnav, a local bird-watcher, told PTI.When Vaishanav went on a stroll along the edge of the lake on Sunday, he took the hundreds of dark lumps strewn across the marshy land for cow dung. But it didn’t take him and his fellow bird watchers Kishan Meena and Pavan Modi to realise the lumps were bodies of hundreds of lifeless migratory birds.Case of bird flu?Carcasses of hundreds of dead birds including plovers, common coot, black winged stilt, northern shovelers, ruddy shelduck, and pied avocet were scattered on the edge of 12-13 km of the catchment area of the lake, leading to a possible number of over 5,000, they said. | Photo Credit: PTI  Forest ranger Rajendra Jakhar said a possible reason could be the hailstorm that hit the area a few days back. Botulism kills migratory birds at Sambhar lakeVolume 90%Press shift question mark to access a list of keyboard shortcutsKeyboard ShortcutsPlay/PauseSPACEIncrease Volume↑Decrease Volume↓Seek Forward→Seek Backward←Captions On/OffcFullscreen/Exit FullscreenfMute/UnmutemSeek %0-9Live00:0001:1401:14   “We estimate about 1,500 birds of about 10 species have died. We are also looking at other possibilities like toxicity of the water, bacterial or viral infection,” he said. A medical team from Jaipur has collected a few carcasses and water samples are being sent to Bhopal for further examination.Ashok Rao, a veterinary doctor and part of the team, said that while the exact reason for the deaths was uncertain, he ruled out the possibility of bird flu.“At initial examination we did not find any sort of secretion from the birds, which is a giveaway in the cases of bird flu,” he said. R G Ujjwal, nodal officer, animal husbandry department, joined Rao and listed possible reasons behind the mysterious calamity. “Their could be some sort of contamination in the water. The increased salinity of the water could also be another reason, as it increases salt concentration in the blood, which can further lead to slow blood flow and the internal organs like the brain may stop working,” Ujjwal said.The lake is also a favourite of flamingos, stilts, stints, garganey, gulls and a number of other species of birds.Lack of a sensible explanationJakhar informed that the lake every year hosts approximately 2-3 lakh birds, which include about 50,000 flamingos and 1,00,000 waders. The strange episode has left villagers and people of the forest department baffled for the lack of a sensible explanation.“I have never seen such a thing in 40 years of my service in the forest department. First I thought it could be because of the hail, but that occurs every year. There is no chemical waste in this water either,” said Ramesh Chandra Daroga, a local working with the forest department.Ashok Sharma, joint director, State Disease Diagnostic Centre, said that once the reason was ascertained further steps will be taken. “We don’t think it is a case of infection, but if it turns out to be the case we will take further steps to make sure it doesn’t spread,” he assured.Meanwhile, the carcasses were collected in a tractor-trolley and buried in a ditch. A total of 669 dead birds were buried while hundreds lay strewn around as the forest staff hesitated to venture into the slippery muddy areas.This is the second such incident in the state within a week. Last Thursday, 37 demoiselle cranes were found dead in Jodhpur’s Khinchan area. Their viscera too have been sent for investigation and reports are awaited. Watch | Botulism kills migratory birds at Sambhar lakelast_img read more

Move over Hrithik Roshan, Salman Khan has signed Rs 1000-crore deal with a channel

first_imgHrithik Roshan was currently in news for beating Salman Khan’s record by selling the rights of six of his films for 550 crores. But the Bajrangi Bhaijaan actor has yet again proved that he is the king of Bollywood. ALSO READ: Hrithik Roshan inks Rs 550-crore deal for satellite rights of upcoming filmsIf reports are to be believed, Salman has signed a new deal with a top television network for a whopping Rs 1000 crores. The deal includes the satellite rights for his next 10 film and for appearances he’ll be making in future on the channel.According to a report in DNA, a trade source said, “Today, stars are raking in the moolah by signing multi-crore deals with channels willing to pay the price. While Ajay Devgn had signed a deal of 400 crore for 10 films with the same channel, at the time, Salman had signed the same for 500 crore starting with Bodyguard – so he was getting paid 50 crore per film then. Varun Dhawan recently inked a deal with a channel where he gets paid 300 crore for 10 films of his.””But with Salman’s past few releases all being blockbusters – Bajrangi Bhaijaan and Prem Ratan Dhan Payo, for example – channels are willing to pay him triple the amount to air his films and have his presence grace their shows – be it reality shows or sports-based programmes. He recently re-negotiated his earlier contract with the same channel,” the source added.The source also told the leading daily, “In such cases, if the production house wants to be paid more, it can pay off the channel by giving it a certain amount and then selling the movie rights to the highest bidder as a one-off deal.”advertisementOn the work front, Salman Khan’s latest film Sultan has set the box office on fire. The film has collected Rs 229.16 crore in nine days of its release. Apart from Salman Khan, the film also stars Anushka Sharma in the lead role. Sultan hit the screens on July 6 this year.last_img read more

Wright goal ends NYCFC’s home unbeaten run

first_imgNew York City’s poor MLS form continued as the New England Revolution ended their winless run with a 1-0 victory on Wednesday.Brian Wright’s second-half goal at Yankee Stadium proved to be the winner for the Revolution, who boosted their playoff chances with the win while handing NYCFC its first home loss of the season. The loss extended City’s winless run to four matches. Article continues below Editors’ Picks Man Utd ready to spend big on Sancho and Haaland in January Who is Marcus Thuram? Lilian’s son who is top of the Bundesliga with Borussia Monchengladbach Brazil, beware! Messi and Argentina out for revenge after Copa controversy Best player in MLS? Zlatan wasn’t even the best player in LA! For the Revolution, the win was  their first victory since June and moved the club to within three points of the sixth-placed of the Montreal Impact in the Eastern Conference.Wright had already struck the post before scoring his first MLS goal in the 71st minute for Brad Friedel’s men.Cristian Penilla’s effort was parried by City goalkeeper Sean Johnson and Wright reacted quickest to tuck away the rebound for the match-winner.While NYCFC’s form has been poor of late, the club remains in solid playoff position, sitting third in the table and 15 points clear of the playoff-chasing Revolution.last_img read more

Niki Lauda admits Ferrari ‘clearly ahead’ of Mercedes

first_imgMercedes’ non-executive chairman Niki Lauda has called on his side to make “two steps forward” if they want to catch up with Ferrari in the upcoming Barcelona Grand Prix.Mercedes utterly dominated Formula One between 2014 and 2016, but in 2017 season so far Ferrari’s Sebastian Vettel has pulled out lead in the drivers’ championship.Vettel is standing at the top of the standings with 86 points ahead of Mercedes pair of Lewis Hamilton (73 points) and third-placed Valterri Bottas (63 points).Admitting that Ferrari is ‘clearly ahead’ of Mercedes this season, Lauda said that it is high time for his team to realize what is not working and take steps accordingly in the upcoming races.”Ferrari is clearly ahead. We need to analyse what exactly is not working and take the right steps for Barcelona. Because all the teams will bring updates, Ferrari will make a step forward, we have to make two and Red Bull needs to make three,”Sport24 quoted Lauda as saying.There have been speculations that the biggest problem with Mercedes is its inconsistency with the tyres, but Lauda ruled out the same.”We have too much weight in the car, we need to improve the aerodynamics, and above all we need to understand why the new Pirelli tyres do not work as they do on the Ferrari,” the Mercedes chairman said.last_img read more

Victoria Azarenka to miss Fed Cup final against USA amid child custody battle

first_imgFormer world number one Victoria Azarenka is all set to miss Belarus’ Fed Cup final against the USA as she continues to battle for custody over her baby son, team chiefs has confirmed.The 28-year-old had also skipped this year’s US Open in August after a Los Angeles judge, who is presiding in a custody case over her 10-month old son Leo, had ruled that the child must stay in California until his future is being decided.Downplaying that Azarenka’s absence would have any effect on their performance, Belarus team captain Eduard Dubrov insisted his young side are capable of overcoming the same in their first Fed Cup final, which will be played at the Minsk’s Chizhovka Arena on November 11 and 12.”The progress that our young girls have made in recent months gives me confidence in our team’s prospects in the final.Victoria (Azarenka) will be unable to come to play for the reasons that everybody knows. It’s a pity but we just can’t change anything right now,” Sport24 quoted Dubrov, as saying.19-year-old Aryna Sabalenka will spearhead the Belarus squad along with Aliaksandra Sasnovich and Vera Lapko, while doubles specialist Lidziya Morozova was Dubrov’s surprise pick as she rejoins Belarus for the first time since 2013.last_img read more

Want to put cricketers into a good place for IPL: BBL head

first_imgBy Mona Parthsarathi Melbourne, Sept 24 (PTI) Indian Premier League (IPL) is the world’s best domestic competition and Big Bash League (BBL) head Kim McConnie hopes it will continue to lead the way and provide a roadmap for other leagues in the world. “Hats off to IPL. It is by far the best domestic competition in the world,” Kim told PTI Bhasha at Melbourne Cricket Ground. “We often say that BBL is being used as a launch pad where cricketers around the world can showcase their talent and hopefully put them into a good place for the IPL,” she added. With a firm focus on growing the Women’s League, Big Bash last year appointed Kim as its head. She joined Cricket Australia from PepsiCo, where she was Head of Sports Marketing at the company’s global headquarters in New York. “IPL has shown the roadmap for the other leagues in the world. We pay great attention to the IPL and notice what they are doing especially from the talent point of view. It will continue to lead the way in many factors,” Kim said. “We learnt from the IPL many things like fan engagement. Lot of our players come back with a lot of great stories from IPL. We have borrowed from IPL the concept of merging sports with entertainment and now BBL is like family entertainment where whole family come and sit together to watch matches.” Asked how difficult it is to keep the league clean from menaces like fixing, Kim said: “CA’s integrity team is doing great work. We stand by our clean record. Most important is that our players and coaches take it seriously and will continue to do so.”advertisement She is quite happy with the success graph of BBL and the way women Cricket is gaining popularity through WBBL. “We are moving into eighth year of BBL and have shown rapid growth. We are now able to fill stadium like MCG with 6070 thousand people coming to watch BBL games,” Kim said. “Players like Ricky Ponting are talking about it and it is now seen on the global scale as a dynamic domestic league. “WBBL is into the fourth season and it is the best women’s league around the world. We are very proud that some of Indian female players are also a part of it. It is very dynamic and gaining a lot of interest and I am sure it will lead the way for others,” she added. BBL is touching new grounds this year with an increase in number of venues and matches. “This season is full home and away and we are having 16 extra games. This will lead BBL to new destinations, new markets and new fans. BBL matches will be held in Gold Coast, Geelong, Canberra, Alex Springs for the first time,” Kim said. Other sports like Soccer is providing a lot of competition to cricket leagues but Kim said they are ready to accept the challenges. “Leagues like BBL and IPL are very important for the game of cricket. Our aim is to inspire the next generation to pick up cricket bat may be in the backyard, whether in our formal participation programme or beach Cricket,” she said. “We have 1.5 million kids playing cricket and one third of them are girls. The growth is phenomenal. We are making it sure that all the kids across Australia have the ability to play cricket where and when they want.” PTI MJ ATKATKlast_img read more

Commission Issues Investor Alert

first_imgThe Nova Scotia Securities Commission is alerting investors that Vincenzo Pettinicchio, NPFB Europe SRL, Montreal Tickets and World of Tickets are not registered to sell securities in Nova Scotia. This person and these companies have solicited Nova Scotia residents by Internet advertisements, such as Kijiji, to invest in ticket resale companies. Shortly after the NPFB Europe SRL advertisement was removed from the Internet, advertisements soliciting investments for Montreal Tickets and World of Tickets surfaced on the Internet using the same contact information. The commission urges Nova Scotians to use extreme caution when dealing with firms that are not registered in Nova Scotia. It is illegal to solicit investments in the province without registering with the commission and complying with Nova Scotia securities laws. To see if a company or person is registered, you can check the Canadian Securities Administrators’ National Registration Search: http://www.securities-administrators.ca/nrs/nrsearchprep.aspx?ID=1325 . To report a scam: http://nssc.novascotia.ca/recognize-and-report-scam . The Nova Scotia Securities Commission is the provincial government agency responsible for regulating the investment industry in the province. -30-last_img read more

Rainy morning in city

first_imgNew Delhi: Delhiites woke up to a rainy Sunday morning with the minimum temperature settling at 24.8 degrees Celsius, two notches below the season’s average.Humidity was recorded at 98 per cent. The Safdarjung observatory, the recording for which is considered official for the city, received 45.7 mm of rainfall while Palam received 11.4 mm rainfall till 8.30 am.The Lodhi Road observatory received 49.9 mm rainfall while the Ridge received 65.8 mm rainfall. Ayanagar received 20.8 mm rainfall till 8.30 am. The weatherman has forecast generally cloudy skies with the possibility of light to moderate rain/thundershower with the maximum temperature likely to settle around 30 degrees Celsius. On Saturday, the maximum temperature settled at 29 degrees Celsius, five degrees below the season’s average, while the minimum temperature was recorded at 25.2 degrees Celsius, one notch below the average.last_img read more

Dead birds fall from southern US sky experts befuddled

first_imgAPTN National NewsA mysterious case of bird deaths has wildlife officials in the U.S. southern states scratching their heads.About 3,000 red-winged blackbirds were found dead or dying in Beebe, Ark., last week. If that wasn’t bad enough, then another 500 blackbirds were found dead just over the border in Louisiana.The cause of the deaths remains unknown and wildlife officials in both states are sending bodies to the lab for study.Some have speculated that the deaths may have been caused by heart attacks, bad weather or fireworks.Last week, hundreds of thousands of drum fish washed up dead along a 20 kilometre stretch of the Arkansas River.last_img read more

Liberal lawmakers challenge Trump with drug cost legislation

first_imgWASHINGTON — Challenging the Trump administration on a high-profile consumer issue, leading congressional liberals plan to unveil a package of bills Thursday designed to radically reduce what Americans pay for prescription drugs by linking prices to lower costs in other countries.The legislation has little chance of becoming law under a divided government, but it could put Republicans on the defensive by echoing themes and ideas that President Donald Trump has embraced at one time or another. The common denominator: Americans shouldn’t have to pay more for critical medications than consumers pay in other economically advanced countries.The Trump administration has put forward its own plan for reducing drug prices.Independent Sen. Bernie Sanders of Vermont and Democratic Rep. Elijah Cummings of Maryland plan to introduce the three bills on Thursday, according to the senator’s office. Cummings chairs the House Oversight and Government Reform committee, which is planning to take a major role on drug pricing issues.A new idea in the package would open up generic competition to patent-protected U.S. brand-name drugs that are deemed “excessively priced.” A second bill would allow Medicare to directly negotiate with drugmakers. The third bill would allow consumers to import lower-priced medications from Canada.“If the pharmaceutical industry will not end its greed … then we will end it for them,” Sanders said in a statement.The federal Health and Human Services Department would get a major new mission regulating drug prices.As a presidential candidate, Trump initially called for Medicare to negotiate drug prices and favoured allowing Americans to import lower-priced medications from abroad, something that many consumers already do even if it is not legal.But those ideas are political nonstarters for most Republicans, who favour a free-market approach to the U.S. pharmaceutical industry and prize its capacity for innovation.As president, Trump has unveiled a complex plan to lower drug costs, relying on dozens of regulatory actions. A key goal is to eliminate incentives for major actors like drugmakers, pharmacy managers and insurers to stifle competition at the expense of consumers. Independent experts say the administration’s proposals would have an impact but they don’t limit the ability of drug companies to set high prices.Time and again, Trump has complained that other countries where governments set drug prices are taking advantage of Americans. Indeed, one of his ideas would shift Medicare payments for drugs administered in doctors’ offices to a level based on international prices.“We are taking aim at the global freeloading that forces American consumers to subsidize lower prices in foreign countries through higher prices in our country,” the president said in unveiling that proposal shortly before last year’s congressional elections.Sanders and Cummings would go far beyond Trump’s proposals. Their legislation would essentially apply to any U.S. patent-protected brand-name drug, whether or not government programs are bearing its costs. By comparison, Trump’s international pricing proposal would not apply to retail pharmacy drugs purchased by Medicare beneficiaries or to medications for privately insured people.Under the lawmakers’ plan, drugs deemed “excessively priced” by HHS could face generic competition. A medication’s cost would be deemed “excessive” if its price in the U.S. is higher than the median, or midpoint, price in Canada, the United Kingdom, Germany, France and Japan.If the manufacturer is unwilling to cut its U.S. price, then the government could allow generic manufacturers to make a more affordable version of the medication. Generic companies taking on the task would have to pay “reasonable” royalties to the company holding the patent.The pharmaceutical industry is already adamantly opposed to Trump’s international pricing idea and is likely to fight the lawmakers’ proposal even harder.Ricardo Alonso-Zaldivar, The Associated Presslast_img read more

Ggn family threatens mass suicide over police inaction

first_imgGurugram: Mohammad Sajid and his family that was subjected to physical violence on the day of Holi in Gurugram’s Bhoop Singh area, has now threatened to commit mass suicide over police inaction. The family has accused district police and civil administration of favouring the goons and have claimed that they are being pressured to withdraw the FIR. “The matter is in public domain. Everyone knows how goons have deliberately attacked us in a preplanned manner. Still, the district police are not helping us and allowing alleged attackers and their family members to threaten us to withdraw the FIR,” said Mohamad Akhtar, one of the victims.”They come to our house and abuse our women and girls. If the district administration and police will not help us to bring justice in this case, we will go for mass suicide,” Akhtar said. The victim’s family has submitted a memorandum to Sohna SDM for a speedy trial. “The local police have registered FIR against two youths of our family in a bid to put pressure on us,” Akhtar said. Meanwhile, Gurugram (South) DCP Himanshu Garg said that both the groups were involved in the altercation. The police had arrested 10 persons for attacking the family on March 21. There was a change in events when there was a cross-FIR was filed against the family. This riled the family to an extent that even planned to leave the city till they were stopped in doing so by the top police officials. The Muslim family in Gurugram that was attacked by a mob of 12-20 people on the day of Holi (March 21) with rods and sticks. The family had been living in Gurugram for the past 15 years. According to the FIR registered at Bhondsi police station, the incident took place when Sajid’s relatives had come to visit on Holi. In the complaint, Sajid’s nephew, Dilshad, alleged that they were playing cricket in a vacant plot near the house when some boys confronted them and said, “What are you doing here? Go to Pakistan and play.” When Sajid intervened, one of the two men on the bike slapped him, Dilshad alleged. In the moments that followed, the duo was joined by several others, allegedly armed with sticks, rods and swords, who barged into the family’s home, attacked them and stole their valuables. Videos recorded by the victims show them trying to close the door to the terrace, even as the accused try to break it down. In the video, a group of men can be seen beating up a man with rods and sticks, while another lies in the corner, even as two women plead with the attackers to stop.last_img read more

Advertising regulation changes

Vehicle manufacturers will seek to comply with the latest change in advertising regulations within the timeframe set by the revised DfT and VCA guidelines. Vehicle manufacturers already make detailed CO2 information available in a variety of formats at point of sale and in advertisements. In 2005 vehicle manufacturers introduced the voluntary colour coded labelling scheme, giving more than the statutory minimum information, which is now recognised as best practice by the European Commission. Car buyers are increasingly aware of CO2 emissions from vehicles and manufacturers continue to deliver lower-carbon cars to the market place, helping to reduce emission and alleviate high fuel costs.Click to share on Facebook (Opens in new window)Click to share on Twitter (Opens in new window) read more

The Last Time The Chiefs Were This Good They Won A Super

3D. Culpepper2004MIN4-172.21766183127.0 9T. Brady2015NWE5-070.61699141118.4✓ NE61NE66NE+0.1– DAL53GB57GB+6.7– OAK68%OAK58BAL+9.4– The Kansas City Chiefs’ Week 5 win over the the Houston Texans was significant for several reasons. It squashed any lingering doubts about who the NFL’s best team is, as the league’s only 4-0 team moved to 5-0. It also solidified KC’s place atop our NFL projections, as we now give them a 97 percent chance of making the playoffs and an 81 percent chance of earning a coveted first-round bye. But perhaps the team’s most impressive achievement so far is this: These are the best Chiefs since KC’s last (and only) championship team, 48 years ago.Using Elo, our pet metric for judging a team’s strength at any given moment, we can trace the various incarnations of the Chiefs week by week in NFL history. Their current Elo rating of 1701 is the highest it has been since the team hit its all-time peak rating of 1775 after defeating the Vikings in Super Bowl IV. Of the 899 weeks for which we have Elo data on this team, there are only eight in which Kansas City’s rating was higher than it is right now — and all of them came in that 1969 campaign, in the last year of the AFL. Move over, Len Dawson, make room for Alex Smith.But we have certainly seen hot starts from Andy Reid’s team before. They started the 2013-14 season 9-0 and then lost five of their next seven regular-season games before bowing out to the Indianapolis Colts in the AFC Wild Card game. So will this year be any different?The defense has regressed since the 2013 season, surrendering 22.2 points per game through five games, compared with 19.1 for the whole of the 2013 season. But they’ve maintained respectability despite losing star safety Eric Berry, who went down for the season with a torn Achilles tendon in the team’s opening-night road win over the New England Patriots. And any step back here has been more than compensated for by improvements on offense. Led by Smith and rookie running back Kareem Hunt, the offense is off to a blistering pace, averaging an NFL-best 32.8 points per game, 5.9 points better than the 2013 team managed to produce.This may be hard to digest, but Smith is having one of the best starts to a season of any quarterback in NFL history. In almost every major offensive category — passing completion rate, passer rating, adjusted yards per attempt and interceptions — Smith ranks among the best. Here are the best season-opening five-game stretches ever, according to passer rating, among QBs who made more than 150 passing attempts in that span in any season since 1950. 4A. Smith2017KAN5-076.61391110125.8 BUF51BUF57CIN-9.3– MIN58MIN64MIN+2.0– 7M. Ryan2016ATL4-169.11740122121.6✓✓ In addition to having the fourth-best passer rating in this time frame, Smith has yet to throw an interception. And among these quarterbacks, Smith’s completion rate of 76.6 percent is the highest. The table above puts Smith in some nice company: Every QB joining him is either a Hall of Famer already or will likely be one soon — with the exception of Daunte Culpepper. (And unlike Culpepper, Smith doesn’t have the luxury of being able to heave jump balls to Randy Moss.) In this group, Culpepper and Smith also stand out as the only ones to not start at least one Super Bowl in their career to date. Culpepper may be alone in that regard after this season.In the PittsKansas City’s Week 6 opponent had a slightly less glorious Week 5. In fact, the Pittsburgh Steelers suffered one of the worst losses in their 85-year history. Ben Roethlisberger threw five interceptions in a brutal 30-9 loss at home to the Jacksonville Jaguars (yes, them). The Steelers’ loss was so bad that they dropped 55 Elo points, the 49th-worst single-game drop in more than 30,000 NFL games, and the franchise’s third-worst loss ever. Steelers fans may not want to remember the two worse losses, but we’ll remind them anyway: a 24-6 defeat at home to the newly formed Houston Texans in 2002 and a 34-10 thumping on the road against the previously winless Cincinnati Bengals in 1979 (ouch!).The latest loss means Roethlisberger is under intense pressure to retire, with even the two-time Super Bowl winner admitting that he might not have it anymore. That, along with the quarterback’s public spat with wide receiver Antonio Brown in Week 4, means the Steelers could be in a minor crisis. Pittsburgh finds itself 3-2 and atop the AFC North standings, with the Baltimore Ravens and Cincinnati Bengals lurking just behind. Looking at the underwhelming slate of opponents the Steelers have played so far — the Cleveland Browns, Minnesota Vikings, Chicago Bears, Baltimore Ravens and Jacksonville Jaguars — gives even more cause for concern. The Steelers travel to the Chiefs next week before a home game against their bitter rivals the Bengals and a visit to the surprisingly good Detroit Lions. The rest of October could alter Big Ben’s plans in 2018.FiveThirtyEight vs. the crowdWeek 5 in our NFL prediction game — in which we invite you to pick football games and try to outsmart our Elo algorithm — was much better for you readers than the previous two weeks had been — readers were just 21 points behind the Elo predictions in Week 5 compared with 146.2 points behind in Weeks 3 and 4 combined. The readers made gains mostly by being less wrong than our algorithm. Both Elo and the readers picked the Oakland Raiders to beat the Ravens and the New York Giants to beat the Los Angeles Chargers, and neither of those picks worked out. However, the average reader was less confident in either the Raiders or the Giants of winning than Elo was, so readers lost fewer points on those misplaced bets.The biggest net gain for Elo came in the Miami Dolphins’ win over the Tennessee Titans. Even without factoring in that the Titans’ Marcus Mariota was inactive for the game, Elo put its faith in Jay Cutler and the Dolphins and was rewarded. (Never doubt Jay Cutler! Haha, no, we’re kidding. Definitely doubt him.) That’s it for this week — be sure you make your picks for Week 6. NYG68NYG59LAC+9.0– 8D. Marino1984MIA5-065.21527153121.6✓✓ Source: Pro-football-reference.com QBYEARTEAMW-LCOMP %YDSTDINTPASSER RATINGWON DIV.?MADE SB? OUR PREDICTION (ELO)READERS’ PREDICTION 10D. Brees2009NOR5-069.21400132118.4✓✓ PICKWIN PROB.PICKWIN PROB.WINNERREADERS’ NET PTS NYJ65NYJ59NYJ-7.3– 6K. Warner2000RAM5-072.11947147122.0 1P. Manning2013DEN5-075.8%1884201136.4✓✓ 5A. Rodgers2011GNB5-071.71721142122.9✓ PIT80PIT79JAX+0.0 Alex Smith is in royal company … plus Daunte CulpepperTop passer ratings among quarterbacks who have thrown at least 150 attempts in a team’s first five games of a season, since 1950 DET63DET59CAR+2.6– SEA55SEA51SEA-6.3– KC67KC65KC-4.1– 2T. Brady2007NWE5-074.11383162128.7✓✓ PHI65PHI67PHI-0.6– Elo’s dumbest (and smartest) picks of Week 5Average difference between points won by readers and by Elo in Week 5 matchups in FiveThirtyEight’s NFL prediction game IND75IND62IND-11.3– MIA59TEN51MIA-11.9– read more

CMS Cepcor major expansion progressing

first_imgCMS Cepcor has recently been granted planning permission to substantially expand their facilities at their Coalville headquarters in the UK. This new expansion includes the construction of a new purpose built head office that will incorporate its research and development, inspection, sales, administration and crusher training facilities alongside the substantial expansion of its existing crusher parts storage and distribution warehousing.The new development of the facilities in Coalville is planned to commence shortly and to be completed in Q1 2015. This latest development follows the recent substantial investment in the CMS Cepcor™ technical centre in Coalville which was commissioned in 2013. This subsequently included the integration of Baguley Precision Engineers, the wholly owned UK manufacturing subsidiary business of CMS Cepcor into its Precision Services Division.The new technical centre represented a substantial investment in new premises, and CNC manufacturing capability, which has further enhanced the manufacturing, inspection and repair facilities in Coalville and provided greatly improved manufacturing efficiency for the company. These approved facilities include CNC, milling, turning, boring, slotting, grinding, drilling, pressing, welding, co-ordinate measuring, material testing and assembly. Alongside the UK manufacture of crusher, screen, feeder and coating plant spare parts, the company is also experienced as a machining contractor for other industries.Lee Hodges, Commercial Director, commented: “In recent years CMS Cepcor has increasingly consolidated manufacture of our precision machined crusher spare parts in-house and the expansion facilities in Coalville will help to ensure we remain the genuine alternative to the original equipment manufacturer.”last_img read more

Police in Derry investigating serious and malicious paramilitarystyle attack on teenager

first_imgPolice in Derry investigating ‘serious and malicious’ paramilitary-style attack on teenager The assailants all wore masks. Tweet thisShare on FacebookEmail this article 9,874 Views Sunday 11 Jun 2017, 11:43 AM POLICE IN DERRY are investigating a report of a serious and malicious assault on a teenager.The in the Gartan Square area of Derry, just after midnight yesterday.Chief Inspector Alan Hutton said:“The assault has all the hallmarks of a paramilitary-style attack, with the assailants all wearing masks.“These attackers set upon a vulnerable 15-year-old boy with iron bars – and the victim sustained a number of broken bones as a result.“Anyone who has information that could help with our investigation should contact detectives at Strand Road, using the non-emergency number 101 and quoting reference number 28 of 10/6/17.”Alternatively, if someone would prefer to provide information without giving their details they can contact the independent charity Crimestoppers and speak to them anonymously on 0800 555 111.Read: London-bound flight diverted over ‘suspicious conversation’ 18 Comments Jun 11th 2017, 11:43 AM Gartan Square Image: Google Mapscenter_img http://jrnl.ie/3438142 Share Tweet Email Image: Google Maps Gartan Square By Paul Hosford Short URLlast_img read more

Séisme les habitants des HautesPyrénées secoués en pleine nuit

first_imgSéisme : les habitants des Hautes-Pyrénées secoués en pleine nuitTarbes, Hautes-Pyrénées, France – Les habitants de 120 communes des Hautes-Pyrénées, situées au sud-est de Tarbes, ont été secoués en pleine nuit par un léger séisme hier, jeudi 1er avril. La zone, étendue sur 117 km à partir de l’épicentre, a été touchée par un tremblement de terre de magnitude 4,3 jeudi dernier, à 3h36. Heureusement, ce dernier n’a fait ni victime, ni dégât.  À lire aussiInternet pourrait être le meilleur système au monde pour détecter les séismesSelon les 185 habitants interrogés par le Bureau central de Strasbourg, la secousse a duré de 3 à 5 secondes, les réveillant dans leur sommeil en ce jour de poisson d’avril. Certains habitants éloignés de l’épicentre l’ont également ressentie, notamment dans le Gers et la Haute-Garonne.Selon Matthieu Sylvander, sismologue à l’observatoire Midi-Pyrénées, si le tremblement de terre a été ressenti aussi loin, c’est qu’il a eu lieu dans une zone de la croûte terrestre plus profonde que les séismes habituels. Il explique, sur le site de La Dépêche : “Généralement, les séismes se produisent aux alentours de cinq à six kilomètres. La plus grande profondeur de celui-ci explique qu’il n’y ait pas eu de dégâts, mais aussi que les gens aient pu le ressentir aussi loin”. L’épicentre du séisme a été situé entre Aspin et Arreau, dans une zone montagneuse. Il s’agit du plus important séisme depuis deux ans dans le secteur. Le dernier, recensé le 15 octobre 2009, avait atteint une magnitude de 3,9. Le 2 avril 2010 à 12:47 • Emmanuel Perrinlast_img read more

Vancouver man dies at Weyerhaeuser mill in Longview

first_imgLONGVIEW — A 50-year-old Vancouver man died Saturday afternoon while working on an electrical project at Weyerhaeuser, Longview police said Sunday.Scott Trapp, a JH Kelly contractor, was installing electrical wiring at the facility when a co-worker noticed “he was down” about 5 p.m., Longview Sgt. Troy Brightbill said.On-site employees performed CPR and tried to revive Trapp with an automated external defibrillator but were unsuccessful, Brightbill said. Longview firefighters also were unable to revive Trapp, who was declared dead at the scene, Brightbill said.The Cowlitz County Coroner’s Office is investigating the cause of death and should have more information today.last_img read more

Coconut Creek woman safely located after going missing

first_imgCOCONUT CREEK, FLA. (WSVN) – Police have safely located a previously missing woman from Coconut Creek.Coconut Creek Police said 21-year-old Yanique Mauge left her house to walk to Broward College on Wednesday. She was safely found just after noon, Thursday, and has returned home.Copyright 2019 Sunbeam Television Corp. All rights reserved. This material may not be published, broadcast, rewritten or redistributed.last_img

Walker may call gas line special session in October

first_imgGov. Bill Walker (File photo by Skip Gray/360 North)Gov. Bill Walker may call a special session of the Legislature next month to consider the Alaska LNG Project. Walker spokeswoman Katie Marquette says his decision isn’t final yet, but he’s been talking to legislators about dates, and he’s considering the third week in October.Download Audio:“The state has until the end of the December to decide whether to buy out TransCanada’s position in  a gas line, so that matter needs to be handled before the regular session,” she said.Walker wants the state to buy TransCanada’s share of the project, which he says would give the state a real seat at the table. He estimates it would cost about $100 million.Senate Majority Leader John Coghill of North Pole says Walker has a good case to make for the buyout.“My guess is there’s a good chance of him being successful,” Coghill said. “But a lot of it depends upon what other pieces are laid out with it. The previous briefings that we’ve had, there was a lot of unanswered questions yet that we’re hoping that they will bring with them to the special session.”The governor has to give legislators 30-days notice. The Legislature held two special sessions this spring to resolve the state budget.last_img read more